Encouraging signs our immune system may be able to fight off Covid-19 reinfection – CNN

This suggested that patients who had recovered from Covid-19 could be reinfected and get sick all over again. Antibody-induced immunity lasting six months to a year is what we often observe with the human coronaviruses which
cause the common cold. If this early study was to be trusted in full, this truly would be terrible news.
Another article describing quickly diminishing antibody levels was published
in June and followed up with a
second report in July showing a similar result. The latter paper showed that, on average, patients’ antibody levels tended to fall by half around 36 days after the onset of symptoms, while a small portion of those sampled declined much more slowly.

The science seemed to be confirming my initial fear that antibody immunity would not be enough to protect recovered coronavirus victims from reinfection.

But then the science progressed further. A series of publications in recent weeks on antibody responses to vaccines and an elegant serological study — an examination of antibodies in your blood — moved the focus of our knowledge. Both the
Oxford and
Moderna vaccines generated a robust antibody response, as high or higher than what is generated by a mild or moderate infection with live SARS-CoV-2 virus. These vaccines are like a school for your immune system, they teach your body how to respond to a virus without producing disease. This was good news! If the antibody level starts higher, it will possibly persist for longer than previously reported. The limitation is that we still need time to determine how long the antibodies will persist — and whether they will be shown to prevent infection with the virus in the real world.
Additionally, the
serological study, posted as a pre-print by a research team at Mount Sinai Hospital in New York City, demonstrated quite clearly that after a mild to moderate Covid-19 infection, antibody levels declined from their peak, then maintained a steady level for at least three months.

It also showed that this immune response was capable of neutralizing the virus, providing the recovered patient with a strong sign of what could be some level of immune protection. This study differed from the early antibody studies in that the number of patients assessed was much larger — it included nearly 20,000 patient blood samples (more than 9x the sample size of the larger previous studies) and the methods were designed to specifically measure the concentration of the antibodies against the virus’ spike protein that allows it to enter our cells. Though it has not yet been peer reviewed the study’s comprehensive methods make it the best example yet of serological research on coronavirus.

It is not that the early studies were wrong, they just hadn’t considered how their data related to the battle for immunity. In battle, you aim to overwhelm your opponent with strength of numbers and superior armament. This is also true for the immune system’s antibody response.

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