Targeting Nsp1 with montelukast (Singulair) helps prevent shutdown of host protein synthesis. Credit: Mohammad Afsar
An oral medication used to treat asthma and allergies can bind to and block a crucial protein produced by the SARS-CoV-2 virus, and reduce viral replication in human immune cells, according to a new study by researchers at the Indian Institute of Science (IISc).
Approved by the US Food and Drug Administration (FDA), the drug, called montelukast, has been around for more than 20 years and is typically prescribed to reduce inflammation caused by conditions like asthma, hives, and hay fever. In the United States, montelukast is sold under the brand name Singulair.
In the study published recently in the journal eLife, the researchers show that the drug binds strongl...