Rare genetic variants protect against obesity, study says – Daily Mail
Sixteen rare genetic variants could protect people from being obese, a new study claims.
Researchers performed 'whole exome sequencing' – an extensive genetic test that looks at thousands of genes at once – on more than 645,000 people.
They identified 16 variants that influence body mass index (BMI), the standard measurement for determining if people are of a normal weight, overweight or obese.
Rare genetic mutations in one of the genes, called GPR75, was associated with protection against obesity.
People with at least one inactive copy of GPR75 weighed about 12 pounds less and faced a 54 per cent lower risk of obesity than those without the mutation.
Carriers of the mutation had a 1.9 kg/m2 lower BMI on average – an almost two point reduction.
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