Month: May 2021

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates – Nature.com
Health & Fitness

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates – Nature.com

1.Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012). ADS  CAS  PubMed  PubMed Central  Google Scholar  2.Zetsche, B. et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell 163, 759–771 (2015). CAS  PubMed  PubMed Central  Google Scholar  3.Strecker, J. et al. Engineering of CRISPR–Cas12b for human genome editing. Nat. Commun. 10, 212 (2019). ADS  CAS  PubMed  PubMed Central  Google Scholar  4.Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Programmable editing of a target base in genomic DNA without d...
I wish I could live a normal life: What your friend with an anxiety disorder wishes you knew – USA TODAY
Health & Fitness

I wish I could live a normal life: What your friend with an anxiety disorder wishes you knew – USA TODAY

Many people have anxiety – but not everyone has an anxiety disorder. The Mayo Clinic describes clinical anxiety disorders as involving "repeated episodes of sudden feelings of intense anxiety and fear or terror that reach a peak within minutes (panic attacks)." Different types of anxiety disorders include generalized anxiety disorder, social anxiety disorder and separation anxiety disorder.  Anxiety disorders may be more common than you think: About 31% of U.S. adults will experience an anxiety disorder over the course of their lives. Treatments range from therapy to medication to mindfulness.  Experts recommend seeking medical attention if anxiety is interrupting your work or other parts of your life; if you have suicidal thoughts, get medical care as soon as possible. But what does an a...
Covid-19 Vaccines Don’t Work as Well for People With These Conditions – Gizmodo
Health & Fitness

Covid-19 Vaccines Don’t Work as Well for People With These Conditions – Gizmodo

A vial of the Pfizer/BioNTech covid-19 vaccinePhoto: Jeff Chiu (AP) Research is beginning to make clear that certain groups of people won’t enjoy the same level of highly effective protection provided by covid-19 vaccines as everyone else. Studies are finding that people who are immunocompromised are less likely to develop immunity against the coronavirus after vaccination. Even before the vaccine rollout began in earnest last late year, experts expected that people with weakened immune systems would be less protected by vaccination. It’s already known that the virus can cause more serious illness and survive far longer in immunocompromised people, thanks to a weaker immune response generated against it. This same weak immune response could also make the immunocompromised more suscept...
Loki realizes how screwed he is in the new Loki trailer – Polygon
Lifestyle & Arts

Loki realizes how screwed he is in the new Loki trailer – Polygon

In the newest preview for Loki, our favorite Marvel villain listens to a mascot tell him about his impending trial by the Time Variance Authority. Because of course an omnipotent secret agency would have a loveable mascot named Miss Minutes to help streamline their bureaucratic process! Loki picks up immediately after the events of Avengers: Endgame — but not the big events. When the crew traveled back in time to the first Avengers film, that version of Loki grabbed the Tesseract to escape ... and, according to the upcoming Disney Plus series, he immediately got arrested by the TVA. Now, he needs to fix the timeline, along with TVA officer Mobius M. Mobius (Owen Wilson). Loki looks like a romp through iconic MCU moments, with all the reality-warping, time-hopping hijinks that would ...
Paul Mooney, Chappelles Show comedian and actor, dead at 79 – New York Post
Lifestyle & Arts

Paul Mooney, Chappelles Show comedian and actor, dead at 79 – New York Post

Paul Mooney, the actor-comedian famous for his roles in “The Buddy Holly Story” and “Bamboozled,” has died at 79. Mooney passed away Wednesday morning in Oakland, California, his daughter Spring Mooney confirmed on Twitter. The cause of death was a heart attack, according to reports. “Give me a moment,” Spring said in the emotional tweet. “My best friend just died and my world is forever SHOOK !!! I really can’t put into words right now my feelings .. know that I LOVE THIS MAN AND I AM BROKEN.” Mooney was best known for playing Sam Cooke opposite Oscar nominee Gary Busey in 1978’s “The Buddy Holly Story.” He also played Junebug in Spike Lee’s acclaimed 2000 comedy “Bamboozled.” The Shreveport, Louisiana, native got his start as a writer, backing ...
Kendall Jenner Catching Backlash for 818 Tequila Ad Campaign – TMZ
Lifestyle & Arts

Kendall Jenner Catching Backlash for 818 Tequila Ad Campaign – TMZ

Play video content @drink818 / Instagram Kendall Jenner's new tequila ad has a lot of people up in arms, claiming the supermodel is taking advantage of Mexican culture to push her new beverage. KJ is featured in the new promotional spot for her 818 Tequila on an agave farm in Jalisco, Mexico ... where her operation is running. The video and pics feature a lot of native farmers -- with Kendall alongside them rocking pig tails, as well as what some describe as traditional Mexican garb. ...
New Mask Guidelines Don’t Take a Huge Number of Americans Into Account – Slate
Health & Fitness

New Mask Guidelines Don’t Take a Huge Number of Americans Into Account – Slate

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Iowa surpasses 400,000 positive COVID-19 tests – KCCI Des Moines
Health & Fitness

Iowa surpasses 400,000 positive COVID-19 tests – KCCI Des Moines

SPORTS WITH SCOTT REISTER POWERED BY FAREWAY"> (ááá1-SHOTá) áá (áááSCOTTááá) THE CDC GUIDANCE CHANGED, DRAKE EAD SEIT'S RESTRICTIONS, AND THIS WEEK'S STATE TRACK MEET CAN HAVE FU LL CAPACITY - UP TO 14 THOUSA ND 500 CHEEINRG ON THEIR LOVED ONES AND THAT IS WHAT THE HH SCHOOL STATE MEET IS ALL ABOUT. IT'S ABOUT RUNNERS LIKE HOOVER FRESHMAN JESSICA KINE. HER FAMILY IS FROM LIBERIA. LAST WEEK SHE QUALIFIED FOR FOUR EVES NT AT STATE. INSTEAD OF ONLY TWO TICKETS, NOW HER LAR FAMILY WILL ALL GETOT HOOVER HAS 16 ATHLET ES HEADED THERE. JUNIOR CHARLES WALKER IS ONE OF THEM. SINCE THE WSNE CAME OU T THIS MORNING....HE HAS BEEN DRAMING OF RUNNING IN FRONT OF A PACKED HOUS TICKETS ARE ON SALE NOW. THE STATE MEET IS THURSDAY FRIDAY SATURDAY THE MORNING SESSIONS FO R...
Covid-19 vaccine rollout for ages 12 to 15 is better than expected, health officials say – CNN
Health & Fitness

Covid-19 vaccine rollout for ages 12 to 15 is better than expected, health officials say – CNN

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‘Batman: Caped Crusader’: Animated Series From Bruce Timm, J.J. Abrams, Matt Reeves Greenlit At HBO Max & Cartoon Network – Deadline
Lifestyle & Arts

‘Batman: Caped Crusader’: Animated Series From Bruce Timm, J.J. Abrams, Matt Reeves Greenlit At HBO Max & Cartoon Network – Deadline

Batman: Caped Crusader, an animated series from executive producers Bruce Timm, J.J. Abrams and Matt Reeves, received a straight to series order from HBO Max and Cartoon Network. The reimagining of the Batman mythology is produced by Warner Bros. Animation, Bad Robot Productions and 6th & Idaho and marks Batman: The Animated series producer Timm’s return to Batman in animated episodic series. The Animated SEries. Tom Ascheim, President, Warner Bros. Global Kids, Young Adults and Classics (GKYAC) and Sam Register, President, Warner Bros. Animation (WBA) and Cartoon Network Studios (CNS), unveiled the series on Wednesday. “It is always fun to feed the insatiable appetite fans have for all things Batman. Batman: Caped Crusader will entertain first time and die-hard fans alike and, ...